If the area around your blister becomes red, warm, and very painful you need
to see a physician. Infection can occur, especially in large blisters that have
been torn or improperly opened. If you have a blister in an area that has not
been injured by friction with shoes or clothing, see a doctor immediately to
rule out any serious conditions.
Now that you have that sucker under control, let’s talk about how to prevent
more. If you are wearing shoes that rub or constrict your feet, you may want to
consider new shoes. Unless you just can’t part with the $300 Italian leather
stilettos with crystal detailing. In that case, rub some Vaseline or other
lubricant over the areas that receive the most friction.
If your blisters come from sports and running shoes, your sock may be to
blame. Avoid 100% cotton socks, they will just soak up sweat, become wet and
rub your foot (also will grow bacteria like a Petri dish). Try wearing a thin
liner sock under a thicker sports sock. That way the liner sock receives the
friction, protecting your skin.