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Designer Children: The Future of Germline Gene Therapy 
 
by Mark R. Whittington October 13, 2005

Genetic Prescreening

In 1978, the first in vitro fertilization procedure or IVF was conducted, which allows for otherwise infertile parents to have children. The technique involved removing a woman’s egg from her uterus, fertilizing it in a lab, and then implanting the fertilized egg back into the uterus. IVF has resulted in the ability to “prescreen” a fertilized embryo for genetic disorders that can lead to conditions like down syndrome, cystic fibrosis, hemophilia, and hemophilia. Eggs that contain these traits can be discarded in favor of those that do not. Some parents have already used this technique to determine the desired sex of their child. This is a rudimentary step along the road to the ability to alter the genetic code of an embryo to determine the physical and personal traits of a child.

Genetic Manipulation in Plants and Animals

The genes of animals and plants have been manipulated for a number of years in order to produce desirable traits. Food plants that are resistant to certain diseases and pests as well as creating higher yields have been created. Goats and cows that produce more milk, with greater amounts of protein have been created. Mice have been produced with a predetermined disease, such as cancer, to facilitate medical research.

Germline Gene Therapy

Germline gene therapy involves altering the genetic makeup of an embryo, or even a human sperm or egg, by inserting or deleting certain genes in order to determine physical and personal traits. These changes would not only alter the genetic code of the child that will be born from the embryo but, since his or her reproductive cells will also be altered, every descendent the child will have.

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