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Panic Disorder: Description, Diagnosis, and Treatment 
 
by Jimmy McShean July 21, 2005

The Causes of Panic Disorder

The cause of panic disorder had been theorized in different ways over the years. The causes seem to vary from person to person, but the two major reasons are biology and heredity.

Biological Reasons for Panic Disorder

Psychologists with a biological approach to their field have their own explanation for what causes panic disorder. According to these biological psychologists, people who suffer from panic disorder suffer from a lack of the neurotransmitter serotonin in their brains. Serotonin is the neurotransmitter that regulates sleep, mood, and appetite. Everyone has serotonergic fibers that travel through the amygdala and the hippocampus. These are the regions of the brain that interpret sensory stimuli, like fear. People with panic disorder usually have damaged serotonergic fibers in their brains, causing a flaw in the way their brains interpret the sensation of fear. They suddenly experience fear, even when there is no fear to experience.

Hereditary Factors

Various research by many psychologists has yielded evidence that flaws in both dominant and recessive genes are significant causes of panic disorder in the children of parents with panic disorder. Many different kinds of studies have been done to confirm this. Some of these include family studies, in which the genes of different members of a family are compared; twin studies, in which twin babies are studied for their genes; and linkage studies, in which DNA links from parents are compared to DNA from their children. All results seem to point to a genetic cause for the disorder.

There is not one main cause. Both of these factors play a significant role in the cause of panic disorder.

Treatment

Because there is not just one cause for panic disorder, treatment for the disorder varies from person to person. No research has been done as of yet to determine which method of treatment is best.

There are 2 major methods of treatment that have been proven to work better than any other method: the use of antidepressants, specifically tricyclic antidepressants (TCAs) to increase the level of serotonin in the brain; and the use of serotonin selective reuptake inhibitors (SSRIs) for the same purpose. Different methods work for different people and no research has been done as of yet to determine a link between the cause of the disorder and the medication.

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